Omifin: mechanism of action, indications, uses and adverse effects
El Clomiphene citrate (Omifin) It is an oral medication that works by inducing ovulation. It is therefore a drug that can be Very useful in women with chronic anovulation and desire to conceive.
Clomiphene citrate (Omifin)
Mechanism of action
Clomiphene Citrate behaves as a ovulation inducer through an anti-etrogenic action at the hypothalamic level. This increases the secretion of the pituitary hormones FSH and LH, the latter two of which act at the ovarian level, promoting follicular development and selection and, therefore, ovulation.
Indications
The main indication of Omifin is treatment of women suffering from infertility due to chronic anovulation, the most relevant subgroup being that of patients with polycystic ovary syndrome.
Use: Omifin
The use of Omifin can restore normal ovulation in a specific group of patients, helping to achieve pregnancy through directed intercourse.
The use of this drug should always be supervised by a gynecologist, and Its use is not recommended for more than 6 months in a row
The daily dose of Clomiphene Citrate is 100 mg. That is, 2 tablets of Omifin daily, which They are usually taken from the 5th to the 9th day of the cycle, controlling in parallel, the correct follicular development through serial ultrasounds.
Adverse effects
You have few side effects if taken at the recommended dose (50-100 mg daily). These may include hot flashes, headaches, nausea and vomiting, breast pain, and intermenstrual bleeding.
It is important to highlight the increased risk of multiple pregnancy, and therefore the importance of ultrasound monitoring ovarian stimulation, cancelling treatment in those patients where the response has been greater than expected.
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Article written by the Dr. Sebastián Ignacio Sessa Méndez.
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